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Studies Currently Enrolling

ED-STARS (Emergency Dept. Screen for Teens at Risk for Suicide)

Biosignatures II

Press Releases

FLUID study result are being presented at Pediatric Academic Societies 2017 Annual Meeting (PAS). 

Saturday, May 6th
3-5pm Platform Presentation
Session: Emergency Medicine 1
Effects of Fluid Infusion Rate and Sodium Content on Acute and Long-term Neurological Outcomes of Pediatric Diabetic Ketoacidosis (DKA): The Pediatric Emergency Care Applied Research Network (PECARN) Fluid Therapies Under Investigation in DKA (PECARN FLUID) Trial
Presenter: Nathan Kuppermann, MD, MPH Authors: Kuppermann N, Ghetti S, Schunk J, Stoner M, Rewers A, McManemy JK, Myers S, Nigrovic LE, Garro A, Brown K, Quayle KS, Trainor JL, Bennett J, DePiero A, Tzimenatos L, Kwok M, Perry CS, Dean JM, Olsen CS, Casper TC, Glaser N, for the Pediatric Emergency Care Applied Research Network (PECARN) 4/28/17


The In-Hospital THAPCA Trial paper was published on January 24, 2017 in the New England Journal of Medicine. It was the largest pediatric clinical trial conducted to study temperature management after cardiac arrest. The design of this study began in the early 2000s and enrollment was between 2009-2015.

Thank you to everyone from the division of pediatric critical care who over the years had a part – small or large - in the protocol development, database creation & validation, data cleaning, project management, in-person training sessions, medical monitoring, subject enrollment and follow-up, statistical analysis, and manuscript preparation. It was certainly a team effort. Thank you!



Congratulations to Drs. Nigrovic, Mahajan, Tzimenatos, Alpern, Rogers, Casper, Ramilo and Kuppermann. Their PECARN abstract "The Accuracy of the Yale Observation Scale Score and Unstructured Clinician Suspicion to Identify Febrile Infants Aged <=60 Days with Serious Bacterial Infections" won "Best Abstract" in the Emergency Medicine category at the AAP meeting held in October 2015.Lise Nigrovic and Prashant Mahajan



Personalized Screen to ID Suicidal Teens in 14 ERs Press Release 9/23/14


Do Probiotics help kids with Stomach Bugs? 7/2/14


Annual Scientific Grant Writing Workshop

This is a valuable workshop for grant writers who want to improve their skills and receive guidance on research oriented grant writing.

This year's workshop will be held on AUGUST 22-24, 2018 in CHICAGO, IL.

Attendees will work on each section of their research grant proposal, receive continual feedback from experienced grant writers, and leave with a well-defined draft.

Visit for online registration.

Performance Measures toolbox

Training module for investigators

Recent Publications

Meert KL, Slomine BS, Christensen JR, Telford R, Holubkov R, Dean JM, Moler FW; Therapeutic Hypothermia after Pediatric Cardiac Arrest Trial Investigators. Family burden after out-of-hospital cardiac arrest in children. Pediatr Crit Care Med. 2016 Jun;17(6):498-507. PubMed PMID: 27124565; PubMed Central PMCID: PMC4893912.

Moler FW, Hutchison JS, Nadkarni VM, Silverstein FS, Meert KL, Holubkov R, Page K, Slomine BS, Christensen JR, Dean JM; Therapeutic Hypothermia After Pediatric Cardiac Arrest Out-of-Hospital Trial Investigators. Targeted temperature management after pediatric cardiac arrest due to drowning: Outcomes and complications. Pediatr Crit Care Med. 2016 Aug;17(8):712-720. PubMed PMID: 27362855.

Borgialli DA, Mahajan P,  Hoyle JD Jr, Powell EC, Nadel FM, Tunik MG, Foerster A, Dong L, Miskin M, Dayan PS, Holmes JF, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN).  Performance of the pediatric Glasgow Coma Scale score in the evaluation of children with blunt head trauma. Acad Emerg Med. 2016 Aug;23(8):878-84. Epub 2016 Aug 1. PubMed PMID: 27197686.

Mahajan P, Kuppermann N, Mejias A, Suarez N, Chaussabel D, Casper TC, Smith B, Alpern ER, Anders J, Atabaki SM, Bennett JE, Blumberg S, Bonsu B, Borgialli D, Brayer A, Browne L, Cohen DM, Crain EF, Cruz AT, Dayan PS, Gattu R, Greenberg R, Hoyle JD Jr, Jaffe DM, Levine DA, Lillis K, Linakis JG, Muenzer J, Nigrovic LE, Powell EC, Rogers AJ, Roosevelt G, Ruddy RM, Saunders M, Tunik MG, Tzimenatos L, Vitale M, Dean JM, Ramilo O; Pediatric Emergency Care Applied Research Network (PECARN). Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger. JAMA. 2016 Aug 23-30;316(8):846-57. PubMed Central PMCID: Pending

Silverstein FS, Slomine BS, Christensen J, Holubkov R, Page K, Dean JM, Moler FW.  Functional Outcome Trajectories After Out-of Hospital Pediatric Cardiac Arrest. Crit Care Med. Epub 2016 Aug 9.  PubMed PMID: 27509385 

Stanley RM, Johnson MD, Vance C, Bajaj L, Babcock L, Atabaki S, Thomas D, Simon HK, Cohen DM, Rubacalva D, Adelson PD, Bulloch B, Rogers AJ, Mahajan P, Baren J, Lee L, Hoyle J, Quayle K, Casper TC, Dean JM, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN).  Challenges enrolling children into traumatic brain injury trials: An observational study.  Acad Emerg Med. 2017 Jan 24(1):31-39. Epub 2016 Sep 12. PubMed PMID: 27618167

Meert KL, Telford R, Holubkov R, Slomine BS, Christensen JR, Dean JM, Moler FW; Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) Trial Investigators. Pediatric Out-of-Hospital Cardiac Arrest Characteristics and Their Association With Survival and Neurobehavioral Outcome. Pediatr Crit Care Med. 2016 Dec 17(12):e543-e550. Pubmed PMID: 27679965 

Tunik MG, Powell EC, Mahajan P, Schunk JE, Jacobs E, Miskin M, Zuspan SJ, Wootton-Gorges S, Atabaki SM, Hoyle JD Jr, Holmes JF Jr, Dayan PS, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN). Clinical Presentations and Outcomes of Children With Basilar Skull Fractures After Blunt Head Trauma. Ann Emerg Med. 2016 Oct;68(4):431-440.e1. Pubmed PMID: 27471139

Tham E, Swietlik M, Deakyne S, Hoffman JM, Grundmeier RW, Paterno MD, Rocha BH, Schaeffer MH, Pabbathi D, Alessandrini E, Ballard D, Goldberg HS, Kuppermann N, Dayan PS; Pediatric Emergency Care Applied Research Network (PECARN). Clinical Decision Support for a Multicenter Trial of Pediatric Head Trauma: Development, Implementation, and Lessons Learned. Appl Clin Inform. 2016 Jun 15;7(2):534-42. PMCID: PMC4941858

Zonfrillo MR, Macy ML, Cook LJ, Funai T, Stanley RM, Chamberlain JM, Cunningham RM, Alpern ER; Pediatric Emergency Care Applied Research Network (PECARN). Anticipated resource utilization for injury versus non-injury pediatric visits to emergency departments. Inj Epidemiol. 2016 Dec;3(1):12. PMCID: PMC4853460

Grundmeier RW, Masino AJ, Casper TC, Dean JM, Bell J, Enriquez R, Deakyne S, Chamberlain JM, Alpern ER; Pediatric Emergency Care Applied Research Network.Identification of Long Bone Fractures in Radiology Reports Using Natural Language         Processing to support Healthcare Quality Improvement. Appl Clin Inform. 2016 Nov     9;7(4):1051-1068. PubMed PMID: 27826610

Meert KL, Telford R, Holubkov R, Slomine BS, Christensen JR, Dean JM, Moler FW; THAPCA Trial Investigators. Exploring the safety and efficacy of targeted temperature management amongst infants with out-of-hospital cardiac arrest due to apparent life threatening events.  Resuscitation. 2016 Oct 11;109:40-48. PubMed PMID: 27737774

Babcock L, Olsen CS, Jaffe DM, Leonard JC; Cervical Spine Study Group for the Pediatric Emergency Care Applied Research Network (PECARN). Cervical spine injuries in children associated with sports and recreational activities. Pediatr Emerg Care. 2016 Sep 30. [epub ahead of print] PubMed PMID: 27749628.

PECARN, the Pediatric Emergency Care Applied Research Network, is the first federally-funded pediatric emergency medicine research network in the United States. PECARN conducts high-priority, multi-institutional research on the prevention and management of acute illnesses and injuries in children and youth of all ages.

PECARN is supported by cooperative agreements between seven academic medical centers and the Health Resources Services Administration / Maternal and Child Health Bureau / Emergency Medical Services for Children Program (HRSA / MCHB / EMSC).