PECARN Network
revised
9/28/15

 

The Effectiveness of Oral Dexamethasone for Acute Bronchiolitis: A Multicenter Randomized Controlled Trial

Clinical Trials URL: http://www.clinicaltrials.gov
Study Type: Interventional
Study Period: January 2004 - April 2006
Enrollment: 598
Consent: Yes

PURPOSE:

This study compared a single dose of oral dexamethasone to placebo in a multicenter, randomized, double blind trial of infants aged 2 to 12 months with first-time bronchiolitis (defined as wheezing within 7 days of onset). This is given as additional therapy beyond any other routine therapy used at that center. No current standard therapy is withheld, and no additional tests or other treatments are part of the study. The primary hypothesis was that dexamethasone would be more effective than placebo in preventing hospital admission. The secondary hypotheses were that dexamethasone would decrease respiratory scores and possibly the duration of the disease when compared to placebo, and that dexamethasone would be as safe and as well tolerated as placebo.

 

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