Pediatric Dose Optimization for Seizures in EMS (PediDOSE)
Pediatric Dose Optimization for Seizures in EMS (PediDOSE)
Summary
Seizures are a common reason why Emergency Medical Services (EMS) are requested for a child, and timely seizure cessation is important to prevent neurologic morbidity, respiratory compromise, and mortality. The overall infrequency of both pediatric cases and continuing education opportunities for EMS providers on this topic contribute to provider discomfort and variability in managing pediatric emergencies, including seizures. Prehospital care is protocol-driven and implementing evidence-based guidelines (EBGs) both standardizes and enhances the quality of prehospital care. One of the first prehospital EBGs focused on pediatric prehospital seizure management. In this EBG, several practices are recommended: the preferred initial use of intramuscular (IM) or intranasal (IN) routes of benzodiazepines over intravenous (IV), intraosseous (IO), or rectal (PR) routes, checking a blood glucose, and allowing two doses of benzodiazepines without online medical approval. Though the EBG does not specify a single benzodiazepine, only midazolam can be given by both IM and IN routes.
Key Publications
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AuthorsWard CE, Adelgais KM, Holsti M, Jacobsen KK, Simon HK, Morris CR et al.JournalAcademic emergency medicine : official journal of the Society for Academic Emergency Medicine (2024)PMID
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AuthorsKornblith AE, Singh C, Innes JC, Chang TP, Adelgais KM, Holsti M et al.JournalScientific reports (2025)PMID
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AuthorsShah MI, Adelgais KM, Chamberlain JM, Wang HE, Morgan LA, Riviello JJ et al.JournalTrials (2025)PMID
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AuthorsJohnson AR, Riches NO, VanBuren JM, Corona AE, Jacobsen K, Yang S et al.JournalAcademic emergency medicine : official journal of the Society for Academic Emergency Medicine (2025)PMID
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