Sickle Cell Improvement: ENhancing Care in the Emergency Department (SCIENCE II)
Sickle Cell Improvement: ENhancing Care in the Emergency Department (SCIENCE II)
Summary
Sickle cell disease is an inherited blood disorder affecting approximately 90,000 people in the United States, of whom 36,000 are children. The sickling of abnormal hemoglobin in red blood cells contributes to inflammation and pain resulting in people with SCD having high rates of ED visits and hospitalizations. Acute care utilization rates in SCD are amongst the highest of any disease, are commonly due to painful vaso-occlusive crises (VOC), and are associated with high admission and readmission rates. Successful adherence to guidelines for VOC care has the potential to significantly impact the health and well-being of patients with SCD and improve their health outcomes.
Key Publications
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TitleAuthorsGwarzo I, Coleman KD, McKinley K, Ellison AM, Alpern ER, Corboy J et al.JournalJAMA pediatrics (2025)PMID
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AuthorsColeman KD, McKinley K, Ellison AM, Alpern ER, Hariharan S, Topoz I et al.JournalPediatric blood & cancer (2023)PMID
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AuthorsColeman KD, McKinley K, Ellison AM, Alpern ER, Hariharan S, Topoz I et al.JournalPediatric blood & cancer (2025)PMID
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